"The Global Herg Screening Market was valued at USD 2.13 billion in 2025 and is projected to reach USD 6.58 billion by 2034, growing at a CAGR of 13.35%."
The hERG Screening Market refers to the global demand for assays and technologies used to evaluate the potential of drug candidates to inhibit the human ether-à-go-go-related gene (hERG) potassium channel. This channel plays a critical role in cardiac repolarization, and its inhibition is strongly associated with a risk of cardiac arrhythmia, particularly Torsades de Pointes. As a result, regulatory authorities worldwide require mandatory hERG screening in the early stages of drug development. The market includes a variety of screening methods such as patch clamp electrophysiology, fluorescence-based assays, and automated high-throughput systems, which are deployed by pharmaceutical companies, contract research organizations (CROs), and academic institutions to ensure cardiac safety.
Growth in the hERG screening market is being driven by increased drug development activity, stricter regulatory oversight, and advances in predictive toxicology. The adoption of automated and high-content screening platforms is enhancing assay throughput and data reproducibility. Additionally, the use of induced pluripotent stem cell-derived cardiomyocytes and in silico models is expanding the market’s technological scope. As precision medicine and biologics gain traction, the industry is seeing demand for more sensitive, scalable, and integrated cardiac safety platforms. The hERG screening market continues to evolve as a vital component in minimizing late-stage drug attrition and improving overall pipeline success rates.
North America hERG Screening MarketThe North American hERG screening market is characterized by strong regulatory oversight, a robust pharmaceutical R&D ecosystem, and rapid adoption of advanced electrophysiological technologies. The region benefits from the presence of leading biotechnology companies and CROs that actively invest in high-throughput patch clamp platforms and automated screening solutions. Demand is fueled by stringent FDA cardiac safety requirements and increasing pipeline complexity involving small molecules, biologics, and cell therapies. Integration of stem cell-derived cardiomyocytes and machine learning models into safety workflows is gaining traction. Companies in the region are also focusing on developing integrated cardiac ion channel testing services that offer comprehensive arrhythmia risk assessments, thereby improving preclinical predictability.
Asia Pacific hERG Screening MarketAsia Pacific is emerging as a high-potential market for hERG screening due to growing clinical research activities, cost-effective service providers, and expanding biopharmaceutical manufacturing. Countries like China, India, South Korea, and Japan are actively upgrading their safety pharmacology infrastructure and promoting international compliance standards. The region is seeing increased outsourcing of preclinical cardiac safety studies from Western markets, along with the establishment of local innovation hubs specializing in ion channel research. Government-supported R&D initiatives and an expanding talent pool in bioelectrophysiology are enabling local firms to compete globally. Asia Pacific presents opportunities for technology vendors offering affordable, scalable, and regulatory-ready screening systems.
Europe hERG Screening MarketThe hERG screening market in Europe is driven by well-established safety assessment guidelines, a strong academic–industry collaborative environment, and innovation in in vitro cardiac models. Regulatory authorities encourage early and thorough cardiac risk evaluation, prompting high adoption of patch clamp and fluorescence-based screening technologies across pharmaceutical and CRO laboratories. The region is seeing growth in the use of patient-derived cardiomyocytes for more predictive arrhythmia modeling. European companies are increasingly focusing on expanding integrated cardiac profiling platforms that assess multiple ion channels simultaneously. With an emphasis on reducing animal testing and improving predictive toxicology, Europe continues to offer a dynamic environment for hERG screening innovation and expansion.
Key Insights
hERG screening is an essential step in preclinical drug development as it helps detect compounds that may cause QT interval prolongation, a known risk factor for potentially fatal arrhythmias such as Torsades de Pointes. Regulatory mandates have made these screenings non-negotiable for pharmaceutical submissions.
The increasing global R&D pipeline for novel therapeutics has significantly expanded the demand for reliable, high-throughput hERG assays. Both large pharmaceutical companies and emerging biotech firms are outsourcing these screenings to CROs to optimize cost and turnaround time.
Technological advancements in patch clamp systems, including automated and high-throughput patch clamp platforms, are enhancing assay precision and productivity. These innovations are helping to overcome limitations of manual systems and support large-scale compound profiling.
Fluorescence-based assays and label-free technologies are gaining popularity as alternative screening methods due to their compatibility with automated systems and cost-effectiveness, although they may require confirmation using gold-standard electrophysiological techniques.
Adoption of stem cell-derived cardiomyocytes, especially those generated from human-induced pluripotent stem cells (hiPSCs), is improving the physiological relevance of hERG assays and supporting better predictability of human cardiac responses.
In silico modeling and artificial intelligence tools are being integrated into cardiac safety profiling, allowing virtual screening of compound libraries and early risk assessment before physical testing, thereby improving pipeline efficiency.
The emergence of integrated safety pharmacology platforms that combine hERG, sodium, and calcium channel assays is streamlining workflow and reducing the likelihood of late-stage clinical failures due to cardiotoxicity.
Global regulatory frameworks such as ICH S7B and E14 encourage comprehensive cardiac safety testing, pushing demand for validated and standardized hERG testing platforms that meet compliance and audit readiness standards.
Asia Pacific is becoming a preferred destination for outsourced hERG screening services, owing to the presence of cost-efficient CROs, growing biopharmaceutical research investments, and expanding clinical trial activities across the region.
Strategic collaborations between assay technology providers, contract research organizations, and pharmaceutical developers are helping to expand service capabilities, ensure regulatory alignment, and accelerate drug development timelines in the hERG screening market.
Market Scope
| Parameter | Detail |
|---|---|
| Base Year | 2024 |
| Estimated Year | 2025 |
| Forecast Period | 2026-2034 |
| Market Size-Units | USD billion |
| Market Splits Covered | By Type , By Ion Channel , By Applications |
| Countries Covered | North America (USA, Canada, Mexico) Europe (Germany, UK, France, Spain, Italy, Rest of Europe) Asia-Pacific (China, India, Japan, Australia, Rest of APAC) The Middle East and Africa (Middle East, Africa) South and Central America (Brazil, Argentina, Rest of SCA) |
| Analysis Covered | Latest Trends, Driving Factors, Challenges, Supply-Chain Analysis, Competitive Landscape, Company Strategies |
| Customization | 10 % free customization (up to 10 analyst hours) to modify segments, geographies, and companies analyzed |
| Post-Sale Support | 4 analyst hours, available up to 4 weeks |
| Delivery Format | The Latest Updated PDF and Excel Datafile |
Herg Screening Market Segmentation
By Type
- Gene KCNH2
- Mutant KCNH2
By Ion Channel
- Voltage-Gated
- Ligand Gated
By Applications
- Antiarrhythmic
- Antipsychotic
- Antibiotics
- Other Applications
By Geography
- North America (USA, Canada, Mexico)
- Europe (Germany, UK, France, Spain, Italy, Rest of Europe)
- Asia-Pacific (China, India, Japan, Australia, Vietnam, Rest of APAC)
- The Middle East and Africa (Middle East, Africa)
- South and Central America (Brazil, Argentina, Rest of SCA)
Key Companies Covered
Abbcam PLC, ABR‑Affinity BioReagents Inc, AstraZeneca plc, Aureus Sciences, AVIVA Biosciences Inc, Cambridge Bioscience Ltd, ChanTest Corporation, Charles River Laboratories, Chemaxon Ltd, Creative Bioarray Inc, Cyprotex Limited, Eurofins‑Cerep SA, Merck KGaA, Molecular Devices LLC, Metrion Biosciences Inc, Nanion Technologies GmbH, Sophion Bioscience Inc, Cellular Dynamics International, B’SYS GmbH, Aurora Biomed Inc, PerkinElmer (Caliper).Recent Developments
July 2025: Schrödinger announced its upcoming launch of a computational predictive toxicology platform including hERG liability modeling, aiming to reduce reliance on animal testing through advanced in silico risk assessment.
April 2025: Metrion Biosciences expanded its ion channel services by introducing GLP-certified hERG screening assays alongside high-throughput patch clamp and fluorescence formats, enhancing compliance-ready drug safety options.
February 2024: A research initiative unveiled CardioGenAI, a machine learning framework capable of redesigning compounds to reduce hERG inhibition while maintaining therapeutic potency, marking a novel in silico safety approach.
What You Receive
• Global Herg Screening market size and growth projections (CAGR), 2024- 2034• Impact of recent changes in geopolitical, economic, and trade policies on the demand and supply chain of Herg Screening.
• Herg Screening market size, share, and outlook across 5 regions and 27 countries, 2025- 2034.
• Herg Screening market size, CAGR, and Market Share of key products, applications, and end-user verticals, 2025- 2034.
• Short and long-term Herg Screening market trends, drivers, restraints, and opportunities.
• Porter’s Five Forces analysis, Technological developments in the Herg Screening market, Herg Screening supply chain analysis.
• Herg Screening trade analysis, Herg Screening market price analysis, Herg Screening Value Chain Analysis.
• Profiles of 5 leading companies in the industry- overview, key strategies, financials, and products.
• Latest Herg Screening market news and developments.
The Herg Screening Market international scenario is well established in the report with separate chapters on North America Herg Screening Market, Europe Herg Screening Market, Asia-Pacific Herg Screening Market, Middle East and Africa Herg Screening Market, and South and Central America Herg Screening Markets. These sections further fragment the regional Herg Screening market by type, application, end-user, and country.
1.1 List of Tables
1.2 List of Figures
2. Herg Screening Market Latest Trends, Drivers and Challenges, 2024- 2034
2.1 Herg Screening Market Overview
2.2 Market Strategies of Leading Herg Screening Companies
2.3 Herg Screening Market Insights, 2024- 2034
2.3.1 Leading Herg Screening Types, 2024- 2034
2.3.2 Leading Herg Screening End-User industries, 2024- 2034
2.3.3 Fast-Growing countries for Herg Screening sales, 2024- 2034
2.4 Herg Screening Market Drivers and Restraints
2.4.1 Herg Screening Demand Drivers to 2034
2.4.2 Herg Screening Challenges to 2034
2.5 Herg Screening Market- Five Forces Analysis
2.5.1 Herg Screening Industry Attractiveness Index, 2024
2.5.2 Threat of New Entrants
2.5.3 Bargaining Power of Suppliers
2.5.4 Bargaining Power of Buyers
2.5.5 Intensity of Competitive Rivalry
2.5.6 Threat of Substitutes
3. Global Herg Screening Market Value, Market Share, and Forecast to 2034
3.1 Global Herg Screening Market Overview, 2024
3.2 Global Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
3.3 Global Herg Screening Market Size and Share Outlook By Product, 2024- 2034
3.4 Global Herg Screening Market Size and Share Outlook By Application, 2024- 2034
3.5 Global Herg Screening Market Size and Share Outlook By End User, 2024- 2034
3.6 Global Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
3.7 Global Herg Screening Market Size and Share Outlook by Region, 2024- 2034
4. Asia Pacific Herg Screening Market Value, Market Share and Forecast to 2034
4.1 Asia Pacific Herg Screening Market Overview, 2024
4.2 Asia Pacific Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
4.3 Asia Pacific Herg Screening Market Size and Share Outlook By Product, 2024- 2034
4.4 Asia Pacific Herg Screening Market Size and Share Outlook By Application, 2024- 2034
4.5 Asia Pacific Herg Screening Market Size and Share Outlook By End User, 2024- 2034
4.6 Asia Pacific Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
4.7 Asia Pacific Herg Screening Market Size and Share Outlook by Country, 2024- 2034
5. Europe Herg Screening Market Value, Market Share, and Forecast to 2034
5.1 Europe Herg Screening Market Overview, 2024
5.2 Europe Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
5.3 Europe Herg Screening Market Size and Share Outlook By Product, 2024- 2034
5.4 Europe Herg Screening Market Size and Share Outlook By Application, 2024- 2034
5.5 Europe Herg Screening Market Size and Share Outlook By End User, 2024- 2034
5.6 Europe Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
5.7 Europe Herg Screening Market Size and Share Outlook by Country, 2024- 2034
6. North America Herg Screening Market Value, Market Share and Forecast to 2034
6.1 North America Herg Screening Market Overview, 2024
6.2 North America Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
6.3 North America Herg Screening Market Size and Share Outlook By Product, 2024- 2034
6.4 North America Herg Screening Market Size and Share Outlook By Application, 2024- 2034
6.5 North America Herg Screening Market Size and Share Outlook By End User, 2024- 2034
6.6 North America Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
6.7 North America Herg Screening Market Size and Share Outlook by Country, 2024- 2034
7. South and Central America Herg Screening Market Value, Market Share and Forecast to 2034
7.1 South and Central America Herg Screening Market Overview, 2024
7.2 South and Central America Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
7.3 South and Central America Herg Screening Market Size and Share Outlook By Product, 2024- 2034
7.4 South and Central America Herg Screening Market Size and Share Outlook By Application, 2024- 2034
7.5 South and Central America Herg Screening Market Size and Share Outlook By End User, 2024- 2034
7.6 South and Central America Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
7.7 South and Central America Herg Screening Market Size and Share Outlook by Country, 2024- 2034
8. Middle East Africa Herg Screening Market Value, Market Share and Forecast to 2034
8.1 Middle East Africa Herg Screening Market Overview, 2024
8.2 Middle East and Africa Herg Screening Market Revenue and Forecast, 2024- 2034 (US$ billion)
8.3 Middle East Africa Herg Screening Market Size and Share Outlook By Product, 2024- 2034
8.4 Middle East Africa Herg Screening Market Size and Share Outlook By Application, 2024- 2034
8.5 Middle East Africa Herg Screening Market Size and Share Outlook By End User, 2024- 2034
8.6 Middle East Africa Herg Screening Market Size and Share Outlook By Technology, 2024- 2034
8.7 Middle East Africa Herg Screening Market Size and Share Outlook by Country, 2024- 2034
9. Herg Screening Market Structure
9.1 Key Players
9.2 Herg Screening Companies - Key Strategies and Financial Analysis
9.2.1 Snapshot
9.2.3 Business Description
9.2.4 Products and Services
9.2.5 Financial Analysis
10. Herg Screening Industry Recent Developments
11 Appendix
11.1 Publisher Expertise
11.2 Research Methodology
11.3 Annual Subscription Plans
11.4 Contact Information
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FAQ's
The Global Herg Screening Market is estimated to generate USD 2.13 billion in revenue in 2025.
The Global Herg Screening Market is expected to grow at a Compound Annual Growth Rate (CAGR) of 13.35% during the forecast period from 2025 to 2034.
The Herg Screening Market is estimated to reach USD 6.58 billion by 2034.
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